Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury
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چکیده
منابع مشابه
Natural antibodies and complement modulate intimal thickening after arterial injury.
Immune factors are involved in modulating neointimal response to arterial wall injury, but the role of individual immune effectors in this response remains unclear. Using a carotid cuff injury model in mice, we tested the role of immunoglobulin isotypes in modulating intimal thickening by using adoptive transfer of splenocytes from WT mice, or the direct administration of IgG or IgM into immune...
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including atherectomy, endarterectomy, and vein or synthetic bypass grafting. These procedures all have in common an element of injury and a subsequent response of the vascular wall to that injury. The accumulation of vascular smooth muscle cells and associated matrix invariably accounts for the bulk of the intimal hyperplastic lesion. For this reason, clinical investigators have focused on pha...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2020
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.120.314383